Selected Publications (Lead-Authored)

Intestinal fructose catabolism promotes obesity and insulin resistance via ileal lacteal remodeling

Lopez ML, Kang T, Espeleta A, Rubtsova VI, Baek J, Songcuan J, Moyer EM, Kim J, Song WS, Jung S, D'Sa N, Anica A, Tran E, Chun Y, Choi W, Jang KH, Kelly ME, Tamburini IJ, Alam YH, Le J, Ramirez CB, Kataru RP, Hong SP, Nicholas DA, Xue KS, Lee G, Bae H#, Jang C# (# Co-corresponding authors)

Sci Adv. 2026 Aug 28;12(35):eaec0481. doi: 10.1126/sciadv.aec0481.

Dietary fibre-adapted gut microbiome clears dietary fructose and reverses hepatic steatosis

Jung S*, Bae H*, Song WS*, Chun Y, Le J, Alam Y, Verlande A, Chun SK, Kim J, Kelly M, Lopez M, Park SH, Onofre D, Baek J, Jang KH, Rubtsova V, Anica A, Masri S, Lee G, Jang C. (* Co-first authors)

Nature Metabolism, 2025 Sep 15. doi: 10.1038/s42255-025-01356-0. Highlighted by Wachsmuth HR et al., Small but mighty: inulin promotes small intestinal bacterial fructose feeding. Nat Metab (2025).

Cross-organ Metabolite Production and Consumption in Healthy and Atherogenic Conditions

Bae H*, Jung S*, Le J*, Tamburini I, Kim J, Wang E, Song WS, Choi W, Jang KH, Kang T, Lopez ML, Ramirez C, Mohanty I, Kelly ME, Kim J, Kim R, Park SH, Baek J, Mendez B, Petrus P, de Aguiar Vallim TQ, Nicholas DA, Smith Q, Lee G, Seldin M, Jang C.

Cell, 2025 Aug 7; 188(16):4441-4455. doi: 10.1016/j.cell.2025.05.001.

Emerging Technologies and Future Directions in Interorgan Crosstalk Cardiometabolic Research

Bae H*, Nguyen CM*, Ruiz-Orera, Mills NL, Snyder MP, Shah SH, Jang C, Hübner N, Seldin M

Circulation Research., 2025 May 23;136(11):1494-1506. doi: 10.1161/CIRCRESAHA.125.325515.

Arteriovenous metabolomics in pigs reveals CFTR regulation of metabolism in multiple organs.

Bae H*, Kim BR*, Jung S*, Le J, Heide D, Yu W, Park SH, Hilkin B, Gasemer ND, Powers LS, Kang T, Meyerholz DK, Schuster VL, Jang C#, Welsh MJ#

J Clin Invest. 2024 May 14:e174500. doi: 10.1172/JCI174500. Highlighted by Sims-Lucas S et al., Cystic fibrosis-related metabolic defects: crosstalk between ion channels and organs. J Clin Invest. (2024).

Metabolic flux between organs measured by arteriovenous metabolite gradients

Bae H, Lam, K., Jang, C.

Exp Mol Med. 2022. 54, 1354–1366.

Dietary Fructose and Fructose-Induced Pathologies

Jung, S*, Bae H*, Song W-S*, Jang, C. (* Co-first authors).

Annu. Rev. Nutr. 2022. 42:4.1–4.22 

Nasal ciliated cells are primary targets for SARS-CoV-2 replication in early stage of COVID-19

Ahn JH, Kim J, Hong SP, Choi SY, Yang MJ, Ju YS, Kim YT, Kim HM, Rahman MDT, Chung MK, Hong SD, Bae H#, Lee CS#, Koh GY# (# Co-corresponding authors)

J Clin Invest. 2021 May 18:148517
Cover article.

endo_cover

Angiopoietin-2–integrin α5β1 enhances vascular fatty acid transport and prevents ectopic lipid–induced insulin resistance

Bae H, Hong KY, Lee CK, Jang C, Lee SJ, Choe K, Offermans S, He Y, Lee HJ, Koh GY

Nat Commun. 2020 Jun 12;11(1):2980. 
Research image selected as the annual cover for Nature Reviews Endocrinology.

YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells

Choi SY*, Bae H*, Jeong SH*, Park I, Cho H, Hong SP, Lee DH, Lee CK, Park JS, Suh SH, Choi J, Jang JY, Onder L, Moon JH, Jeong HS, Adams RH, Kim JM, Ludewig B, Song JH, Lim DS, Koh GY. (* Co-first authors).

Nat Commun. 2020 Jan 24;11(1):519. 

All Publications

  • Zhang RM, Zhu X, Bae H, Zhang J, Li Y, Chen PY, Shen YH, Tellides G, Snyder N, Jang C, Schwartz MA, Arany Z, Simons M. Metabolic control of smooth muscle cell phenotype switching in atherosclerosis. Sci Adv. 2026 Aug 28;12(35):eaef6065. doi: 10.1126/sciadv.aef6065. Epub 2026 Aug 26. PMID: 42647644.
  • Zhou D, Chen Y, Liu P, Zhu K, Holder-Haynes J, Lloyd SJ, La CM, Astapova II, Choa S, Xiong Y, Bae H et al. Genetics-nutrition interactions control diurnal enhancer-promoter dynamics and liver lipid metabolism. Cell Metab. 2025 Aug 19:S1550-4131(25)00356-0. doi: 10.1016/j.cmet.2025.07.010.
  • Andronicos A, Yoneda KC, Lin D-W, Law FV, Bae H et al. Carboxy-Methylation of the Catalytic Subunit of Protein Phosphatase 2A (PP2Ac) Integrates Methionine Availability with Methionine Addicted Cancer Cell Proliferation. Biomolecules. 2025; 15(9):1210. doi.org/10.3390/biom15091210
  • Shojazadeh A, Hadjiabdolhamid N, Lee C, Antunes IM, Bae H et al. Early detection of coronary artery disease using low-dose CT perfusion: An experimental western fat diet study. Int J Cardiol. 2025 Aug 22;442:133793. doi: 10.1016/j.ijcard.2025.133793.
  • Song WS*, Shen X*, Kang D*, Ramirez C, Park SH, Cao Y, Le J, Bae H et al. Nicotinic acid riboside maintains NAD+ homeostasis and ameliorates aging-associated NAD+ decline. Cell Metab. 2025 May 1; doi.org/10.1016/j.cmet.2025.04.007.
  • Ramirez C*, Ahn IS*, Rubtsova V, Cely I, Le J, Kim J, Jung S, Kelly M, Kim Y, Bae H et al. Circulating glycerate predicts resilience to fructose-induced hepatic steatosis. Cell Metab. 2025 Apr 12;S1550-4131(25)00209-8. doi: 10.1016/j.cmet.2025.03.017.
  • Zhou M, Tamburini IJ, Van C, Molendijk J, Nguyen CM, Chang IY, Johnson C, Velez LM, Cheon Y, Yeo RX, Bae H et al. Leveraging genetic correlation structure to target discrete signaling mechanisms across metabolic tissues. eLife. 2024 Jan 15;12:RP88863. doi: 10.7554/eLife.88863.
  • Zhu X, Wang Y, Soaita I, Lee HW, Bae H et al. Acetate controls endothelial-to-mesenchymal transition. Cell Metab. 2023 Jul 11;35(7):1163-1178.e10. doi: 10.1016/j.cmet.2023.05.010.
  • Park S, Belfoul AM, Rastelli M, Jang A, Monnoye M, Bae H et al. Maternal low-calorie sweetener consumption rewires hypothalamic melanocortin circuits via a gut microbial co-metabolite pathway. JCI Insight. (2023) May 22;8(10):e156397. doi: 10.1172/jci.insight.156397.
  • Guan D, Bae H, Zhou D, Chen Y, Jiang C, La CM, Xiao Y, Zhu K, Hu W, Trinh TM, Liu P, Xiong Y, Cai B, Jang C, Lazar MA. Hepatocyte SREBP signaling mediates clock communication within the liver. J Clin Invest. (2023) Apr 17;133(8):e163018. doi: 10.1172/JCI163018.
  • S Choi*, SP Hong*, JH Bae, SH Suh, Bae H et al. (2023). Hyperactivation of YAP/TAZ drives alterations in mesangial cells through stabilization of N-MYC in diabetic nephropathy. Journal of the American Society of Nephrology 10.1681/ASN.0000000000000075, Jan 21, 2023.
  • Durairaj, G., Demir, Ö., Lim, B., Baronio, R., Tifrea, D., Hall, L. V., DeForest, J. C., Lauinger, L., Jebril Fallatah, M. M., Yu, C., Bae H et al. (2022). Discovery of compounds that reactivate p53 mutants in vitro and in vivo. Cell chemical biology, S2451-9456(22)00275-6.
  • Yanru Wu, Chi Wut Wong, Eric N. Chiles, Allyson Mellinger, Bae H et al. (2022). Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance. Cell Metab. 2022 Jul 5;34(7):1042-1053.e6. doi: 10.1016/j.cmet.2022.05.007.
  • Lee, H. W., Xu, Y., Zhu, X., Jang, C., Choi, W., Bae H, Wang, W., He, L., Jin, S. W., Arany, Z., & Simons, M. (2022). Endothelium-derived lactate is required for pericyte function and blood-brain barrier maintenance. The EMBO journal, 41(9), e109890.
  • Verlande A, Chun SK, Goodson MO, Fortin BM, Bae H, Jang C, Masri S. (2021). Glucagon regulates the stability of REV-ERBα to modulate hepatic glucose production in a model of lung cancer-associated cachexia. Sci Adv. Jun 25;7(26):eabf3885.
  • Hong SP*, Yang MJ*, Cho H*, Park I, Bae H, Choe K, Suh SH, Adams RH, Alitalo K, Lim D, Koh GY. (2020). Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi. Nat Commun. 2020 Aug 14;11(1):4102.
  • Kim J*, Park JR*, Choi J, Park I, Hwang Y, Bae H et al. (2019). Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration. Sci Adv. Feb 13;5(2):eaau6732.
  • Lee CK, Jeong SH, Jang C, Bae H, Kim YH, Park I, Kim SK, Koh GY. (2019). Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation. Science. Feb 8;363(6427):644-649.
  • Lee SJ, Lee CK, Kang S, Park I, Kim YH, Kim SK, Hong SP, Bae H, He Y, Kubota Y, Koh GY. (2018) Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction. J Clin Invest. Nov 1;128(11):5018-5033.
  • Kim J*, Park DY*, Bae H, Park DY, Kim D, Lee CK, Song S, Chung TY, Lim DH, Kubota Y, Hong YK, He Y, Augustin HG, Oliver G, Koh GY. (2017). Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma. J Clin Invest. Oct 2;127(10):3877-3896.
  • Kim J*, Kim YH*, Kim J, Park DY, Bae H et al. (2017).YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest. Sep 1;127(9):3441-3461.
  • Hong SP*, Song S*, Cho SW*, Lee S, Koh BI, Bae H et al. (2017). Generation of PDGFRα+ Cardioblasts from Pluripotent Stem Cells. Sci Rep. 2017 Feb 6;7:41840.
  • Lee J, Song J, Kwon ES, Jo S, Kang MK, Kim YJ, Hwang Y, Bae H et al. (2016). CTHRC1 promotes angiogenesis by recruiting Tie2-expressing monocytes to pancreatic tumors. Exp Mol Med. 2016 Sep 30;48(9):e261.
  • Hong KY, Bae H, Park I, Park DY, Kim KH et al. (2015). Perilipin+ embryonic preadipocytes actively proliferate along growing vasculatures for adipose expansion. Development. 2015 Aug 1;142(15):2623-32.

Google Scholar

See Dr. Bae's complete list of publications on Google Scholar.